⚗️ Endocrine🟢 BasicPituitary Hormones

Growth Hormone

The anterior pituitary hormone that drives body growth and shifts metabolism towards using fat and sparing glucose.

Key points

It is released from the anterior pituitary under hypothalamic control: growth-hormone-releasing hormone stimulates it and somatostatin inhibits it.
Many of its growth effects are indirect, acting through insulin-like growth factor 1 (somatomedin C) made by the liver.
Its direct effects are diabetogenic: it raises blood glucose, promotes the breakdown of fat and increases protein synthesis.
Secretion is pulsatile and greatest during deep sleep, and it is increased by exercise, stress, fasting and a low blood glucose.
Excess before the growth plates fuse causes gigantism, while excess after they fuse causes acromegaly with enlarged hands, feet and jaw.
Deficiency in childhood causes short stature with normal body proportions.

Grows bone and muscle, burns fat and spares glucose — and does much of it through liver-made IGF-1.

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⚗️ Endocrine🟢 BasicPituitary Hormones

The anterior pituitary hormone that drives body growth and shifts metabolism towards using fat and sparing glucose.

It is released from the anterior pituitary under hypothalamic control: growth-hormone-releasing hormone stimulates it and somatostatin inhibits it.
Many of its growth effects are indirect, acting through insulin-like growth factor 1 (somatomedin C) made by the liver.
Its direct effects are diabetogenic: it raises blood glucose, promotes the breakdown of fat and increases protein synthesis.
Secretion is pulsatile and greatest during deep sleep, and it is increased by exercise, stress, fasting and a low blood glucose.
Excess before the growth plates fuse causes gigantism, while excess after they fuse causes acromegaly with enlarged hands, feet and jaw.
Deficiency in childhood causes short stature with normal body proportions.

Grows bone and muscle, burns fat and spares glucose — and does much of it through liver-made IGF-1.