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Also known as: hypercortisolism · Cushing syndrome
The clinical state of chronic cortisol excess — central obesity, moon face, purple striae, proximal myopathy, easy bruising, hypertension, glucose intolerance and osteoporosis. Most cases are EXOGENOUS (steroid therapy); endogenous causes are ACTH-dependent (pituitary 'Cushing's disease', ectopic) or adrenal.
Anyone on prolonged glucocorticoids (commonest); endogenous disease is rare (pituitary adenoma, adrenal tumour, or ectopic ACTH — e.g., lung).
No single drug — cause-directed
Caution: Never stop long-term steroids abruptly (adrenal crisis).
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🚩 Report outdated / suggest update