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Also known as: MG · autoimmune neuromuscular junction disease
An autoimmune disorder of the neuromuscular junction (usually anti-acetylcholine-receptor antibodies) causing FATIGABLE weakness that worsens with use and improves with rest — classically ptosis, diplopia, and bulbar and proximal weakness. Myasthenic crisis (respiratory failure) is the emergency.
Bimodal — young women and older men; associated with thymic hyperplasia/thymoma and other autoimmune disease.
Symptomatic; disease control
Caution: Steroids can transiently worsen weakness at initiation; many drugs worsen MG.
Myasthenic crisis
Guidelines change. If something here is out of date, tell us — we keep these current.
🚩 Report outdated / suggest update