Part 9 · Haematology
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Megaloblastic anaemia reflects impaired DNA synthesis, producing macro-ovalocytes, hypersegmented neutrophils and ineffective haematopoiesis. LDH and indirect bilirubin may rise because precursors die in the marrow. Non-megaloblastic macrocytosis includes alcohol, liver disease, hypothyroidism, reticulocytosis, drugs and myelodysplastic neoplasms.
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