Part 2 · Haematology and Immunity
Same concept, other depth: Foundation →
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Haemoglobin = 4 globins + 4 haems (Fe²⁺–protoporphyrin IX). Adult blood: HbA (α₂β₂) ≈ 97%, HbA₂ (α₂δ₂) ≈ 2–3.5%, HbF (α₂γ₂) < 1%. Each gram carries 1.34 mL O₂ when fully saturated. Haem synthesis begins and ends in mitochondria: ALA synthase (rate limiting, needs pyridoxal phosphate) … ferrochelatase inserts Fe²⁺; lead inhibits ALA dehydratase and ferrochelatase.
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