The reasoning: local needs, central overrides
Local: metabolic (↓O₂, ↑CO₂, H⁺, K⁺, adenosine, lactate → vasodilation: active and reactive hyperaemia); myogenic (Bayliss — stretch → constriction; autoregulation); endothelial (NO via eNOS — shear stress, ACh, bradykinin; prostacyclin; EDHF; endothelin‑1 constricts). Neural: sympathetic α₁ (constriction) dominant in skin, splanchnic, renal; β₂ dilation in muscle with adrenaline. Humoral: angiotensin II, vasopressin, adrenaline (α at high dose), natriuretic peptides, bradykinin, histamine.