Part 1 · General Physiology — Cell, Membrane and Body Fluids
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A cotransporter couples the downhill electrochemical movement of one ion (usually Na⁺) to the uphill movement of another solute. The maximum achievable concentration ratio rises with stoichiometry: SGLT1, carrying 2 Na⁺ per glucose, can concentrate glucose far more than SGLT2 (1:1).
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