The reasoning: five cell lineages, one under tonic inhibition
| Cell (approx. share) | Hormone | Regulators |
|---|---|---|
| Somatotroph (~50%) | GH | GHRH, ghrelin ↑; somatostatin, IGF‑1 ↓ |
| Lactotroph (~15–25%) | prolactin | dopamine (D2) ↓ dominant; TRH, oestrogen, suckling, stress ↑ |
| Corticotroph (~15–20%) | ACTH (from POMC, with β‑endorphin, MSH) | CRH, AVP ↑; cortisol ↓ |
| Thyrotroph (~5%) | TSH | TRH ↑; T3/T4, somatostatin, dopamine ↓ |
| Gonadotroph (~10%) | LH, FSH | pulsatile GnRH ↑; sex steroids, inhibin (FSH) ↓ |