Part 9 · Haematology
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Waldenström macroglobulinaemia is lymphoplasmacytic lymphoma with IgM monoclonal protein. The large IgM molecule can cause hyperviscosity, neuropathy, cryoglobulinaemia and bleeding. AL amyloidosis is misfolded light-chain deposition in organs, especially kidney, heart and nerves. POEMS requires polyneuropathy and a monoclonal plasma-cell disorder, with a wider syndrome pattern.
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