Part 1 · General Physiology — Cell, Membrane and Body Fluids
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CFTR (ABCC7, chromosome 7q31.2) is an ABC‑family protein that functions as a cAMP/PKA‑regulated, ATP‑gated Cl⁻ and HCO₃⁻ channel in apical epithelial membranes. ATP binding at the nucleotide‑binding domains gates the pore; it does not pump anions uphill.
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