Part 4 · Gastrointestinal Physiology
Same concept, other depth: Foundation →
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Parietal cell: carbonic anhydrase generates H⁺ and HCO₃⁻; apical H⁺/K⁺‑ATPase secretes H⁺ (K⁺ recycles via apical K⁺ channels) against a >10⁶‑fold gradient; Cl⁻ exits apically; HCO₃⁻ leaves basolaterally via Cl⁻/HCO₃⁻ exchange (alkaline tide). Stimulation inserts tubulovesicles bearing pumps into the canalicular membrane.
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